Value of Transient Elastography Measured With Fibroscan in Predicting the Outcome of Hepatic Resection for Hepatocellular Carcinoma

• DOI: 10.1097/sla.0b013e3182724ce8
• Publication Date: 2012-10-23T04:37:46Z
• Authors: Matteo Cescon; Antonio Colecchia; Alessandro Cucchetti; Eugenia Peri; Luciana Montrone; Giorgio Ercolani; Davide Festi; Antonio Daniele P...
• Keywords: Transient elastography

In Brief Objective: To evaluate the efficacy of preoperative liver stiffness (LS) measurement in predicting postoperative failure (PLF) after hepatectomy for hepatocellular carcinoma (HCC). Background: Hepatectomy HCC cirrhosis is affected by risk PLF, which not completely predictable with common biochemical tests. Transient elastography FibroScan used to calculate degree LS, and it may be applicable patients scheduled estimate perioperative complications. Methods: Ninety-two undergoing were prospectively evaluated FibroScan. Accuracy LS presence cirrhosis, clinical signs portal hypertension (PH) assessed using receiver operating characteristic (ROC) analysis. Results: 2 patients, could performed because obesity; consequently, 90 suitable study. Perioperative mortality was 2.2% (2 patients); PLF occurred 28.9% (26 patients). ROC analysis identified value higher than or equal 15.7 kPa as being at [area under curve (AUC) = 0.865, 95% confidence interval: 0.776–0.928; sensitivity 96.1%; specificity 68.7%; positive predictive 55.6%; negative 97.8%; likelihood ratio 3.08; 0.056; P < 0.001]. Patients lower 14.8 had no PLF. 12.6 19.6 correlated (AUC 0.880; 0.001), PH 0.786; respectively. Multivariate showed that low serum sodium levels (P 0.012), histological 0.024), elevated 0.005) independent predictors Conclusions: measured a valid tool prediction HCC. Liver day before surgery hepatic resection carcinoma. A transient best cutoff, most reliable factor failure.