A High Fresh Frozen Plasma: Packed Red Blood Cell Transfusion Ratio Decreases Mortality in All Massively Transfused Trauma Patients Regardless of Admission International Normalized Ratio

• DOI: 10.1097/ta.0b013e318227f152
• Publication Date: 2011-08-03T21:10:15Z
• Authors: Lisa M. Brown; Seppo O. Aro; Mitchell J. Cohen
• Keywords: Fresh frozen plasma; Major trauma

Background: Coagulopathy is present in 25% to 38% of trauma patients on arrival the hospital, and these are four times more likely die than without coagulopathy. Recently, a high ratio fresh frozen plasma (FFP) packed red blood cells (PRBCs) has been shown decrease mortality massively transfused patients. Therefore, we hypothesized that with elevated International Normalized Ratio (INR) hospital may benefit from transfusion FFP:PRBC those lower INR. Methods: Retrospective multicenter cohort study 437 was conducted determine whether effect death at 24 hours modified by patient's admission INR hospital. Contingency tables logistic regression were used. Results: Trauma who arrived an had greater risk However, as increased, decreased similarly between quartiles. Conclusions: The similar for all This contrary current belief only coagulopathic ratio. Furthermore, it unnecessary before transfusing Future studies needed mechanism which decreases