Polyomavirus Infection and Its Impact on Renal Function and Long-term Outcomes After Lung Transplantation

• DOI: 10.1097/tp.0b013e3181ae5ff9
• Publication Date: 2009-08-04T07:34:04Z
• Authors: Lora D. Thomas; Aaron P. Milstone; Regis A. Vilchez; Preeti Zanwar; Janet S. Butel; J Stephen Dummer
• Keywords: Adult; Male; Polyomavirus Infections; Heart-Lung Transplantation; Graft Survival; Kaplan-Meier Estimate; Middle Aged; JC Virus; Risk Assessment; 6. Clean water; 3. Good health; BK Virus; Creatinine; DNA, Viral; Odds Ratio; Humans; Female; Kidney Diseases; Prospective Studies; Biomarkers; Follow-Up Studies; Lung Transplantation

Polyomavirus infection causes nephropathy after kidney transplantation but has not been thoroughly investigated in nonrenal organ transplantation.Ninety lung transplant recipients were enrolled, and they provided urine samples for over 4.5 years. Samples analyzed BK virus (BKV), JC (JCV), simian 40 (SV40) by conventional quantitative real-time polymerase chain reaction.Fifty-nine (66%) patients had polyomavirus detected at least once, including 38 (42%) BKV, 25 (28%) JCV, six (7%) SV40. Frequency of shedding serial positive once varied significantly among viruses: 64%; 48%; SV40, 14%. Urinary viral loads BKV (10 copies/mL) JCV higher than SV40 copies/mL; P=0.001 0.0003, respectively). was associated with a pretransplant diagnosis chronic obstructive pulmonary disease (odds ratio 6.0; P=0.016) less common history acute rejection 0.28; P=0.016). sirolimus-based immunosuppression (P=0.037). Reduced survival noted (P=0.03). Patients did have worse renal function those without infection, creatinine clearances lower times when (P=0.038).BKV commonly the recipients; found low frequency. No definite impact on documented. poorer survival.