Increased Soluble Flt-1 Correlates With Delayed Graft Function and Early Loss of Peritubular Capillaries in the Kidney Graft

• DOI: 10.1097/tp.0b013e31829f4772
• Publication Date: 2013-08-02T13:52:24Z
• Authors: Marion Chapal; Mélanie Néel; Florent Le Borgne; Emanuelle Meffray; Odette Carceles; Maryvonne Hourmant; Magalie Giral; Yohann Foucher; Anne Moreau; Fadi Fakhouri
• Keywords: Peritubular capillaries

Ischemia-reperfusion induces tubular and endothelial damage in the renal graft leads to delayed function (DGF) an early loss of peritubular capillaries (PTC). Few, if any, clinical studies have assessed impact proangiogenic antiangiogenic factors on repair during transplantation (RT)-related ischemia-reperfusion.We prospectively kinetics factor soluble Fms-like tyrosine kinase-1 (sFlt-1) 136 consecutive RT patients analyzed sFlt-1 DGF PTC loss.sFlt-1 plasma levels increased by twofold threefold throughout first week after RT. This increase was more marked recipients grafts from deceased donors compared with living donors. Patients had higher at all time points 7 days a peak those without DGF. In multivariate analysis, 250 pg/mL or associated 2.5-fold risk (P=0.04). Similarly, pronounced decrease less than pg/mL.sFlt-1 is new nonimmunologic independent for loss. Its inhibition may help improve outcome