Ventricular Enlargement and its Clinical Correlates in the Imaging Cohort From the ADCS MCI Donepezil/Vitamin E Study

• DOI: 10.1097/wad.0b013e3182677b3d
• Publication Date: 2012-08-24T07:33:23Z
• Authors: Liana G. Apostolova; Sona Babakchanian; Kristy S. Hwang; Amity E. Green; Dimitar Zlatev; Yi-Yu Chou; Charlie DeCarli; Clifford R. Jack; Ronald C. Petersen; Paul S. Aisen; Jeffrey L. Cummings; Arthur W. Toga; Paul M. Thompson
• Keywords: Cognitive Decline; Montreal Cognitive Assessment

We analyzed the baseline and 3-year T1-weighted magnetic resonance imaging data of 110 amnestic mild cognitive impairment (MCI) participants with minimal hippocampal atrophy at from Alzheimer’s Disease Cooperative Study group MCI Donepezil/Vitamin E trial. Forty-six subjects converted to Alzheimer disease (AD) (MCIc), whereas 64 remained stable (MCInc). used radial distance technique examine differences in lateral ventricle shape size between MCIc MCInc associations ventricular enlargement decline. had significantly larger frontal right body/occipital horns relative bilateral frontal, body/occipital, left temporal follow-up. Global decline measured AD Assessment scale subscale Mini-Mental State Examination activities daily living (ADL) were associated posterior enlargement. Decline ADL horn After correction for volume, showed a significant association Executive was