Chronic morphine application is protective against cell death in primary human neurons

• DOI: 10.1097/wnr.0b013e3283186fd7
• Publication Date: 2008-11-13T08:15:11Z
• Authors: Jia Cui; Qiuyue Chen; Long-Chuan Yu; Yan Zhang
• Keywords: Staurosporine

Morphine addiction has become a long-time, serious medical and social problem. To understand the cellular mechanisms of morphine application addiction, effects chronic treatments were examined in primary cultured human neurons. Our results show that, surprisingly, protects neurons against serum deprivation staurosporine induced cytotoxicity. downregulates proapoptotic factor Bax levels In addition, heat shock protein 70 is also involved protection. data suggest that may be beneficial to stimulate cell survival.