Variation in the catechol-O-methyltransferase Val158Met polymorphism associated with conduct disorder and ADHD symptoms, among adolescent male delinquents

• DOI: 10.1097/ypg.0b013e32833511e4
• Publication Date: 2009-12-21T15:40:55Z
• Authors: Colin G. DeYoung; Marya Getchell; Roman A. Koposov; Carolyn M. Yrigollen; Gerald J. Haeffel; Britt af Klinteberg; Lars Oreland; Vladislav V. Ruchkin; Andrew J. Pakstis; Elena L. Grigorenko
• Keywords: Conduct Disorder; Male; Adolescent; Genotype; Catechol O-Methyltransferase; Polymorphism, Single Nucleotide; 3. Good health; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Haplotypes; Attention Deficit Disorder with Hyperactivity; Risk Factors; Humans; Poisson Distribution

Variation in the catechol-O-methyltransferase gene (COMT) has been associated with antisocial behavior in populations with attention deficit/hyperactivity disorder (ADHD). This study examined whether COMT would predict antisocial behavior in a sample with high levels of behavior problems, not necessarily ADHD. In addition, because previous research suggests that COMT may be associated with ADHD in males, association between COMT and ADHD symptoms was examined.This study tested whether variation in three polymorphisms of the COMT gene was predictive of symptoms of conduct disorder and ADHD, in a sample of 174 incarcerated Russian adolescent male delinquents.The Val allele of the ValMet polymorphism was significantly associated with conduct disorder diagnosis and symptoms, whereas the Met allele was associated with ADHD symptoms.The ValMet polymorphism of the COMT gene shows a complex relation to behavior problems, influencing conduct disorder and ADHD symptoms in opposite directions in a high-risk population.