Epidemiological and virological characteristics of people living with HIV on antiretroviral treatment for more than six months in virological failure in Brazzaville, Republic of Congo

• DOI: 10.1099/acmi.0.000805.v2
• Publication Date: 2024-10-17T16:27:51Z
• Authors: Ferdinand Emaniel...; Gervillien Arnold...; Juthèce Privat MA...; Maryse AKOLBOUT; Ghislain LOUBANO-...; Dagene EBOUROMBI; Merlin DIAFOUKA; Gontran ONDZOTTO
• Keywords: Antiretroviral treatment

Introduction Virological failure is one of the major causes treatment failure, and better management HIV infection requires understanding controlling factors that contribute to this phenomenon. The main objective was characterize patients active file Brazzaville Outpatient Treatment Center in virological order identify predictive lead failure. Methods This a cross-sectional study conducted between June December 2020. Patients enrolled were HIV-1 infected from receiving potent combination therapy for at least 6 months but experiencing Viral load determined with automated Abbott Real-time m2000rt System. Sociodemographic clinical data collected computerized patient record software called Santia. Statistical analysis performed independent predictors Results A total 109 recruited. median age 45 years (IQR: 37-52 years) women more represented (74%). More than half had WHO stage IV duration on ARV 96 months. most followed regimen AZT+3TC+EFV (or NVP) 48% while viral 12,985 copies/mL. Conclusion In our study, we did not any sociodemographic or variables However, felt it would be desirable carry out temporal follow-up possibility sequencing different circulating genotypes resistance mutations.