Tossing the coin of ESBL: Prevalence of ESBL-producing Klebsiella pneumoniae isolated from patients with sepsis.

• DOI: 10.1099/acmi.0.000962.v2
• Publication Date: 2025-02-04T11:34:08Z
• Authors: Beatrice Achan; Tonny Luggya; Robert Innocent E...; Simon Sekyanzi; Henry Kajumbula
• Keywords: Klebsiella infections; Klebsiella

Background. Klebsiella pneumoniae is part of the ESKAPE (Enterococcus faecium, Staphylococcus aureus, pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp) group MDR pathogens. It second leading cause nosocomial bloodstream infections, it has a propensity to be drug resistant. Therefore, was aimed determine antibiotic resistance patterns K. isolated from blood cultures patients with features sepsis at Mulago National Referral Hospital, Uganda. Methods The cross-sectional study on utilised (N= 30) positive culture specimens. profile determined by Clinical Laboratory Standards Institute’s Kirby Bauer disk diffusion method, which used classify isolates as susceptible, intermediate, that were resistant third generation cephalosporins subjected extended spectrum b-lactamase (ESBL) screening confirmation using double-disk synergy test cefotaxime, ceftazidime, ceftriaxone, cefotaxime-clavulanic acid, ceftazidime-clavulanic acid. results analysed for frequencies. Results. showed minimum imipenem 13% (4/30) followed amikacin 17% (5/30). There intermediate gentamycin 60% (18/30). However, highest piperacillin; 100% (30/30) sulphamethoxazole-trimethoprim cefepime both showing percentage 97% (29/30). Up 16/30 (53.3%) ESBL production while 14/30 (46.7%) negative. Conclusion. high prevalence ESBL-producing K infection in Uganda’s Hospital.