Study of Clostridioides difficile associated diarrheain Acute care areas of atertiary care centre in Western Rajasthan-a prospective study

• DOI: 10.1099/acmi.0.000969.v2
• Publication Date: 2025-02-17T13:32:16Z
• Authors: Nithya S Roy; Sarika Prabhakar ...; Kumar S Abhishek; Kuldeep Singh; Nikhil Kothari; Daisy Khera; Deepak Kumar
• Keywords: Clostridioides

Purpose The aim of this study is to identify Clostridioides difficile associated diarrhoea (CDAD) in patients admitted acute care units the hospital. It also examines different detection methods, including anaerobic culture, GDH assay, and Toxin A/B ELISA, while exploring how infection relates patient risk factors clinical features. Materials Method Cross sectional conducted Department microbiology over 2 years. Patients >1 year age, who were passing atleast 3 unformed stool 24 hours, with history taking antibiotics included study. Stool samples from collected, one part used for culture another serological testing using Glutamate Dehydrogenase (GDH) ELISA C. difficile. Identification isolates was performed MALDI-TOF MS. results analysed statistical methods. Result Out 180 suspected cases Antibiotic Associated Diarrheal (AAD), 95(52.8%) males. Maximum age group, above 60 years (27.8%) & 51 (15.6%). samples, positive 29 (16%) cases, however 5 (2.8%) samples. Thus, prevalence CDAD found be 2.8%. Isolation (1.7%) cases. 80% confirmed received more than antibiotics. median antibiotic duration among 14 days (IQR = 9). All had a consumption BL-BLI antibiotics, 40% on Meropenem, 20% Ceftriaxone Levofloxacin A possible association between abdominal surgery noted Mortality rate 60%. Conclusion This Western Rajasthan underscores paramount importance early management forestall fatal complications mortality critically ill patients, fostering prudent utilization fortifying antimicrobial stewardship practices hospital setting.