An inactivated whole-virus porcine parvovirus vaccine protects pigs against disease but does not prevent virus shedding even after homologous virus challenge

• DOI: 10.1099/jgv.0.000446
• Publication Date: 2016-03-03T20:12:21Z
• Authors: Tessa Foerster; André Felipe Streck; Stephanie Speck; Hans-Joachim Selbitz; Thomas Lindner; Uwe Truyen
• Keywords: Porcine parvovirus; Viral Shedding; Heterologous

Inactivated whole-virus vaccines against porcine parvovirus (PPV) can prevent disease but not infection and virus shedding after heterologous challenge. Here, we showed that the same is true for a homologous Pregnant sows were vaccinated with an experimental inactivated vaccine based on PPV strain 27a. They challenged day 40 of gestation virulent PPV-27a from which was prepared (homologous challenge). On 90 gestation, fetuses protected disease, while non-vaccinated (control group) exhibited signs disease. All gilts, whether or vaccinated, boost PPV-specific antibodies indicative replication. Low DNA copy numbers, infectious virus, could be demonstrated in nasal rectal swabs immunized sows, high numbers challenge as well both sows.