Genetic background of Cambodian pneumococcal carriage isolates following pneumococcal conjugate vaccine 13

• DOI: 10.1099/mgen.0.000837
• Publication Date: 2022-06-28T17:32:22Z
• Authors: Sophie Belman; Sona Soeng; Chansovannara Sop...; Rebecca Gladstone; Paulina A. Hawkins; Robert F. Breiman; Lesley McGee; Stephen D. Bentley; Stephanie W. Lo; Paul Turner
• Keywords: Carriage; Pneumococcal Conjugate Vaccine; Multilocus sequence typing; Pneumococcal infections

(the pneumococcus) is a leading cause of childhood mortality globally and in Cambodia. It commensal the human nasopharynx, occasionally resulting invasive disease. Monitoring population genetic shifts, characterized by lineage serotype expansions, as well antimicrobial-resistance (AMR) patterns crucial for assessing predicting impact vaccination campaigns. We sought to elucidate background (global pneumococcal sequence clusters; GPSCs) pneumococci carried Cambodian children following perturbation conjugate vaccine (PCV) 13. sequenced pre-PCV13 (01/2013-12/2015,