Histidine at codon 154 of the prion protein gene is a risk factor for Nor98 scrapie in goats

• DOI: 10.1099/vir.0.2008/004150-0
• Publication Date: 2008-11-13T14:43:46Z
• Authors: S. Colussi; G. Vaccari; C. Maurella; C. Bona; R. Lorenzetti; P. Troiano; F. Casalinuovo; A. Di Sarno; M. G. Maniaci; F. Zuccon; R. Nonno; C. Casalone; M. Mazza; G. Ru; M. Caramelli; U. Agrimi; P. L. Acutis
• Keywords: PRNP

Prion protein gene (PRNP) polymorphisms are involved in modulating the appearance of atypical/Nor98 scrapie sheep, with alleles AHQ and AF141RQ strongly associated occurrence disease. The presence histidine at codon 154 has also been detected Nor98-affected goats, but statistical analysis association between Nor98 goat PRNP not reported previously. Here, a case-control study was carried out on eight Nor98-positive goats 246 negative herdmates belonging to Italian outbreaks. results revealed that is disease goats.