Relationships and host range of human, canine, simian and porcine isolates of simian virus 5 (parainfluenza virus 5)

• DOI: 10.1099/vir.0.80200-0
• Publication Date: 2004-09-24T21:12:43Z
• Authors: N. Chatziandreou; N. Stock; D. Young; J. Andrejeva; K. Hagmaier; D. J. McGeoch; R. E. Randall
• Keywords: Simian

Sequence comparison of the V/P and F genes 13 human, canine, porcine simian isolates virus 5 (SV5) revealed a surprising lack sequence variation at both nucleotide amino acid levels (0-3%), even though viruses were isolated over 30 years originated from countries around world. Furthermore, there no clear distinguishing or differences among that correlated completely with species which they isolated. In addition, was evidence ability to block interferon signalling by targeting STAT1 for degradation confined All had an extended cytoplasmic tail in protein, compared original W3A WR monkey isolates. analysis derived human bone-marrow cells London 1980s that, whilst related more closely one another than other isolates, all identifying differences, suggesting independent These results therefore support previous data SV5 can infect humans persistently, although relationship any disease remains highly contentious. Given has been on multiple occasions different species, it is proposed term inappropriate suggested should be renamed parainfluenza 5.