UP-DOWN cortical dynamics reflect state transitions in a bistable balanced network

• DOI: 10.1101/083626
• Publication Date: 2016-10-27T05:12:47Z
• Authors: Daniel Jercog; Alex Roxin; Peter Barthó; Artur Luczak; Albert Compte; Jaime de la Rocha
• Keywords: Bistability; Dynamics; State dependent; Network Dynamics

Abstract In the idling brain, neuronal circuits often exhibit transitions between periods of sustained firing (UP state) and quiescence (DOWN state). Although these dynamics occur across multiple areas behavioral conditions, underlying mechanisms remain unclear. Here we analyze spontaneous population activity from somatosensory cortex urethane-anesthetized rats. We find that UP DOWN are variable (i.e. non-rhythmic) rate shows no significant decay during periods. build a network model excitatory (E) inhibitory (I) neurons exhibits new bistability quiescent state balanced arbitrarily low rate. Fluctuating inputs trigger transitions. Adaptation in E cells paradoxically causes marginal E-rate but marked I-rate, signature validate experimentally. Our findings provide evidence bistable non-rhythmic when brain rests.