Diarrhea may be underestimated: a missing link in 2019 novel coronavirus

• DOI: 10.1101/2020.02.03.20020289
• Publication Date: 2020-02-11T20:35:11Z
• Authors: Weicheng Liang; Zhijie Feng; Shitao Rao; Cuicui Xiao; Ze-Xiao Lin; Qi Zhang; Qi Wei
• Keywords: Coronavirus; Intestinal epithelium

Summary The outbreak of pneumonia caused by the 2019 Novel Coronavirus (2019-nCoV) was reported in Wuhan City, China. However, clinical symptoms varied different reports. Based on results inter-group difference test, we found that incidence diarrhea differed three recent As 2019-nCoV utilizes same cell entry receptor ACE2 as severe acute respiratory syndrome coronavirus (SARS-CoV) and tightly controls intestinal inflammation, to trace route infection mediated 2019-nCoV, used single-cell RNA sequencing data for analysis. We mRNA highly expressed healthy human small intestine rather than lung. Besides, showed significantly elevated proximal distal enterocytes, where epithelium is exposed foreign pathogen. Thus, suspect ACE2-expressing cells might be vulnerable when people eat infected wild animals may serve an indicator infection, suggesting clinicians should pay more attention patients with during pneumonia.