The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

• DOI: 10.1101/2020.02.07.939389
• Publication Date: 2020-02-12T01:06:15Z
• Authors: Linlin Bao; Wei Deng; Baoying Huang; Hong Gao; Jiangning Liu; Lili Ren; Qiang Wei; Pin Yu; Yanfeng Xu; Feifei Qi; Yajin Qu; Fengdi Li; Qi Lv; Wenling Wang; Jing Xue; Shuran Gong; Mingya Liu; Guanpeng Wang; Shunyi Wang; Zhiqi Song; Linna Zhao; Peipei Liu; Li Zhao; Fei Ye; Huijuan Wang; Weimin Zhou; Na Zhu; Wei Zhen; Haisheng Yu; Xiaojuan Zhang; Li Guo; Lan Chen; Conghui Wang; Ying Wang; Xinming Wang; Yan Xiao; Qiangming Sun; Hongqi Liu; Fanli Zhu; Chunxia Ma; Lingmei Yan; Mengli Yang; Jun Han; Wenbo Xu; Wenjie Tan; Xiaozhong Peng; Qi Jin; Guizhen Wu; Chuan Qin
• Keywords: Alveolar cells; Histopathology

Abstract Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the Corona Virus Disease 2019 (COVID-19) cases in China has become a public health emergency of international concern (PHEIC). Based on angiotensin converting enzyme 2 (ACE2) as cell entry receptor SARS-CoV, we used hACE2 transgenic mice infected with SARS-CoV-2 to study pathogenicity virus. Weight loss and virus replication lung were observed SARS-CoV-2. The typical histopathology was interstitial pneumonia infiltration significant lymphocytes monocytes alveolar interstitium, accumulation macrophages cavities. Viral antigens bronchial epithelial cells, epithelia. phenomenon not found wild type infection. clarified Koch’s postulates fulfilled well, mouse model may facilitate development therapeutics vaccines against