Chronic wireless streaming of invasive neural recordings at home for circuit discovery and adaptive stimulation

• DOI: 10.1101/2020.02.13.948349
• Publication Date: 2020-02-15T03:35:17Z
• Authors: Ro’ee Gilron; Simon Little; Randy Perrone; Robert Wilt; Coralie de Hemptinne; Maria S. Yaroshinsky; Caroline A. Racine; Sarah Wang; Jill L. Ostrem; Paul S. Larson; Doris D. Wang; Nick B. Galifianakis; Ian Bledsoe; Marta San Luciano; Heather E. Dawes; Gregory A. Worrell; Vaclav Kremen; David Borton; Timothy Denison; Philip A. Starr
• Keywords: Neurostimulation; Neuromodulation; Local field potential; Neurophysiology; Brain stimulation

Abstract Invasive neural recording in humans shows promise for understanding the circuit basis of brain disorders. Most recordings have been done short durations from externalized leads hospital settings, or first-generation implantable sensing devices that offer only intermittent brief streaming time series data. Here we report first human use an interface wireless multichannel field potentials over long periods, with and without simultaneous therapeutic neurostimulation, untethered to receiving devices. Four Parkinson’s disease patients streamed bilateral 4-channel motor cortical basal ganglia at home 500 hours, paired wearable monitors behaviorally categorize states inadequate excessive movement. Motor state during normal activities was efficiently decoded using either supervised learning unsupervised clustering algorithms. This platform supports adaptive deep stimulation, may be widely applicable disorders treatable by invasive neuromodulation.