Early-life social experience shapes social avoidance reactions in larval zebrafish

• DOI: 10.1101/2020.03.02.972612
• Publication Date: 2020-03-03T10:05:18Z
• Authors: Antonia H. Groneberg; João C. Marques; A. Lucas Martins; Gonzalo G. de Pol...; Michael B. Orger
• Keywords: Social Isolation; Social animal; Social Learning

Summary Social experiences greatly define successive social behavior. Lack of such experiences, especially during critical phases development, can severely impede the ability to behave adequately in contexts. To date it is not well characterized how early-life isolation leads deficits and impacts development. In many model species, challenging fully control because they depend on parental care. Moreover, complex behaviors involve multiple sensory modalities, contexts, actions. Hence, when studying effects, particularly important parse apart from general developmental as abnormal motor learning. Here, we early development zebrafish larvae modulate their behavior, at one week age, avoidance reactions be measured discrete swim events. We show that raising enhanced avoidance, terms reaction distance strength. Specifically, raised use a high-acceleration escape bout, short latency C-start, more frequently interactions. These behavioral differences are absent non-social By ablating lateral line presenting fish with local water vibrations, inputs both necessary sufficient drive reactions. Taken together, our results experience factor shaping mechanosensory larval zebrafish. Highlights Larval Enhanced composed increased distances usage high acceleration swims The organ for