Differential causal involvement of human auditory and frontal cortices in vocal motor control

• DOI: 10.1101/2020.06.08.139881
• Publication Date: 2020-06-09T14:45:22Z
• Authors: Araceli R. Cardenas; Roozbeh Behroozmand; Zsuzsanna Kocsis; Phillip E. Gander; Kirill V. Nourski; Christopher K. Ko...; Kenji Ibayashi; Marco Pipoly; Hiroto Kawasaki; Matthew A. Howard; Jeremy D.W. Greenlee
• Keywords: Auditory feedback; Superior temporal gyrus; Inferior frontal gyrus; Motor Control; Neurocomputational speech processing; Supplementary motor area; Cued speech; Auditory System

Abstract Speech motor control requires integration of sensory and information. Bidirectional communication between frontal auditory cortices is crucial for speech production, self-monitoring control. We used cortical direct electrical stimulation (DES) to functionally dissect audio-motor interactions underlying production Eleven neurosurgical patients performed a visually cued vocal task in which short feedback perturbation was introduced during vocalization. evaluated the effect DES on initiation, voice fundamental frequency (F0) feedback-dependent sites modulated onset latencies. Stimulation different inferior gyrus elicited either shortening or prolongation distinctly F0 at vocalization stages. Frontal temporal areas played an important role setting first 250 ms utterance, while Heschl’s involved later when input available self-monitoring. Vocal responses pitch-shifted were mostly reduced by non-core cortices. Overall, we demonstrate that planning initiation are driven cortices, relies predominantly Our findings represent evidence regions