Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network

• DOI: 10.1101/2020.06.19.20135467
• Publication Date: 2020-06-22T23:22:30Z
• Authors: Gonzague de Pinieux; Marie Karanian-Ph...; Francois Le Loarer; Sophie Le Guellec; Sylvie Chabaud; Philippe Terrier; Corinne Bouvier; Maxime Battistella; Agnès Neuville; Yves-Marie Robin; Jean-Francois Emile; Anne Moreau; Frederique Larous...; Agnes Leroux; Nathalie Stock; Marick Lae; Francoise Collin; Nicolas Weinbreck; Sebastien Aubert; Florence Mishellany; Céline Charon-Barra; Sabrina Croce; Laurent Doucet; Isabelle Quintin-...; Marie-Christine C...; Celine Bazille; Isabelle Valo; Bruno Chetaille; Nicolas Ortonne; Anne Gomez-Brouchet; Philippe Rochaix; Anne De Muret; Jean-Pierre Ghnassia; Lenaig Mescam-Man...; Nicolas Macagno; Isabelle Birtwisl...; Christophe Delfour; Emilie Angot; Isabelle Pommepuy; Dominique Rancher...; Claire Chemin-Airiau; Myriam Jean-Denis; Yohan Fayet; Jean-Baptiste Cou...; Nouria Mesli; Juliane Berchoud; Maud Toulmonde; Antoine Italiano; Axel Le Cesne; Nicolas Penel; Francoise Ducimet...; Francois Gouin; Jean-Michel Coindre; Jean-Yves Blay
• Keywords: Adult; Male; Adolescent; Sarcoma;Metastatic tumors;Cancer epidemiology;Angiosarcoma;Neurological tumors;Skin tumors;Gastrointestinal cancers;Malignant tumors; [SDV]Life Sciences [q-bio]; Science; Neurological tumors; 610; [SDV.CAN]Life Sciences [q-bio]/Cancer; World Health Organization; Young Adult; 03 medical and health sciences; Cancer epidemiology; 0302 clinical medicine; Angiosarcoma; Humans; Malignant tumors; Prospective Studies; Aged; Skin tumors; Incidence; Q; R; Sarcoma; Middle Aged; Gastrointestinal cancers; 3. Good health; Medicine; Female; France; Neoplasm Grading; Metastatic tumors; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology; Research Article

Abstract Background Since 2010, NETSARC and RREPS collected reviewed prospectively all cases of sarcomas tumors intermediate malignancy (TIM) nationwide. Methods The nationwide incidence sarcoma or TIM (2013-2016), confirmed by expert pathologists using WHO classification are presented. Yearly variations correlation with published clinical trials was analyzed. Results 139 histological subtypes reported among the 25172 patients (n=18710, 64%) (n=6460, 36%), respectively n=5838, n=6153, n=6654, n=6527 yearly from 2013 to 2016. Over these 4 years, therefore 79.7, 24.9 95.1/10 6 /year, above that previously reported. GIST, liposarcoma, leiomyosarcomas, undifferentiated represented 13%, 11% tumors. Only as a single entity had 10/million/year. There were 30, 63 66 different an ranging 10 1/10 , 1-0.1/10 < 0.1/10 /year respectively. 2 later “incidence groups” included 21% patients. 8 histotypes varied significantly over this years. Patients per year have higher numbers dedicated phase III II (p<10 −6 ). Conclusions This registry histology experts shows is than reported, incidence<10 much lower access trials.