Expression of ACE2, TMPRSS2 and CTSL in human airway epithelial cells under physiological and pathological conditions: Implications for SARS-CoV-2 infection

• DOI: 10.1101/2020.08.06.240796
• Publication Date: 2020-08-08T04:18:19Z
• Authors: Junping Yin; Brigitte Kasper; Frank Petersen; Xinhua Yu
• Keywords: Rhinovirus; TMPRSS2; Respiratory tract

Abstract SARS-CoV-2 enters into human airway epithelial cells via membrane fusion or endocytosis, and this process is dependent on ACE2, TMPRSS2, cathepsin L. In study, we examined the expression profiles of three entry-related genes in primary isolated from donors with different physiological pathological backgrounds such as smoking, COPD, asthma, lung cancer, allergic rhinitis, cystic fibrosis, viral infections. By reanalyzing 54 GEO datasets comprising transcriptomic data 3428 samples, study revealed that i) smoking associated an increased ACE2 TMPRSS2 a decreased L; ii) infection rhinovirus well poly(I:C) stimulation leads to high all genes; iii) L nasal are patients asthma rhinitis. conclusion, implicates respiratory viruses, cigarette diseases might affect susceptibility development COVID-19.