Oviduct epithelial cells constitute two developmentally distinct lineages that are spatially separated along the distal-proximal axis

• DOI: 10.1101/2020.08.21.261016
• Publication Date: 2020-08-22T11:00:13Z
• Authors: Matthew J Ford; Keerthana Harwalkar; Alain S Pacis; Helen Maunsell; Yu Chang Wang; Dunarel Badescu; Katie Teng; Nobuko Yamanaka; Maxime Bouchard; Jiannis Ragoussis; Yojiro Yamanaka
• Keywords: Oviduct; Fallopian tube; Müllerian mimicry; Homeostasis

Summary Owing to technical advances in single cell biology, the appreciation of cellular heterogeneity has increased, which aided our understanding organ function, homeostasis and disease progression. The oviduct (also known as fallopian tube humans) is distal-most portion female reproductive tract. It essential for reproduction proposed origin high grade serous ovarian carcinoma (HGSOC). In mammals, morphologically segmented along ovary-uterus axis into four evolutionally conserved regions. unknown however if there a diversification epithelial characteristics between these this study, we identified transcriptionally distinct populations secretory multiciliated cells restricted distal proximal regions oviduct. We demonstrated that are lineages specified early Müllerian duct development maintained separately. These results aid development, initiation from