Decreased biofilm formation inProteus mirabilisafter short-term exposure to a simulated microgravity environment

• DOI: 10.1101/2021.04.07.438892
• Publication Date: 2021-04-09T12:55:55Z
• Authors: Dapeng Wang; Po Bai; Bin Zhang; Xiaolei Su; Xuege Jiang; Tingzheng Fang; Junfeng Wang; Changting Liu
• Keywords: Strain (injury)

Abstract Background Microbes threaten human health in space exploration. Studies have shown that P. mirabilis has been found habitats. In addition, the biological characteristics of studied unconditionally. The simulated microgravity environment provides a platform for understanding changes . Objective This study intends to explore effect on , formation biofilm and its related mechanism. Methods strange deformable rods were cultured continuously 14 days under by (HARVs) high-aspect ratio vessels. morphology, growth rate, metabolism strain measured, phenotypic evaluated. Transcriptome sequencing was used detect differentially expressed genes compared with phenotype. Results metabolic ability forming lower than those normal gravity culture condition microgravity. Further analysis showed decrease may be caused down-regulation ( pstS,sodB fumC ). Conclusion It certain reference prevention treatment infection future station exploring exposure