Clostridia isolated from helminth-colonized humans promote hatching of Trichuris muris

• DOI: 10.1101/2022.02.10.479991
• Publication Date: 2022-02-12T01:05:13Z
• Authors: Shushan Sargsian; Ze Chen; Soo Ching Lee; Amicha Robertson; Julia Sproch; Joseph C. Devlin; Mian Zi Tee; Yi Xian Er; Richard Copin; Adriana Heguy; Alejandro Pironti; Victor J. Torres; Kelly V. Ruggles; Yvonne A.L. Lim; P’ng Loke; Ken Cadwell
• Keywords: Clostridia; Trichuris

Abstract Soil transmitted intestinal worms known as helminths colonize over 1.5 billion people worldwide. Although helminth colonization has been associated with altered composition of the gut microbiota, such increases in Clostridia, individual species have not isolated and characterized. Here, we sequenced genome 13 Clostridia from Orang Asli, an indigenous population Malaysia high prevalence infections. Metagenomic analysis 650 fecal samples urban rural Malaysians revealed higher abundance these isolates compared to individuals United States, Peptostreptococcaceae family members displaying a specific association colonization. Remarkably, Asli displayed superior capacity induce hatching eggs murine Trichuris muris . These findings support model which select for microbes that turn their life cycle by promoting egg hatching.