Heart rate variability as biomarker for bipolar disorder

• DOI: 10.1101/2022.02.14.22269413
• Publication Date: 2022-02-16T07:25:10Z
• Authors: Andrea Stautland; Petter Jakobsen; Ole Bernt Fasmer; Berge Osnes; Jim Torresen; Tine Nordgreen; Ketil J Oedegaard
• Keywords: Sample entropy; Photoplethysmogram; Bipolar I disorder

Abstract Bipolar disorder (BD) is characterized by alterations in mood, energy levels and the ability to function. Accordingly, it also associated with dysfunction of autonomic nervous system (ANS), indexed heart rate variability (HRV). Literature concerning differences ANS functioning between mood states still sparse. The main aim study was investigate within-individual changes HRV from manic euthymic bipolar (BD). This first do so using wrist-worn sensors. Seventeen patients BD were equipped photoplethysmography (PPG) sensor wristbands provided 24-hour recordings both during a state state. We calculated mean commonly used measures SDNN, RMSSD, HF, LF Sample Entropy 5-minute segments rest at night. compared within individuals paired t-tests linear regression control for age sex. Recordings 15 analyzed. There statistically significant increases mania euthymia. Effect sizes predominately large. Our findings reveal lower indicates that collected PPG sensors possible biomarker states. Movement artifacts problematic sampling or combination actigraphy recommended. can be further implemented develop monitoring device patients.