Association Between Torque Teno Virus and Systemic Immunodeficiency in Patients With Uveitis With a Suspected Infectious Etiology

• DOI: 10.1101/2023.01.20.23284502
• Publication Date: 2023-01-23T06:35:12Z
• Authors: Ai Fujita Sajiki; Yoshito Koyanagi; Hiroaki Ushida; Kenichi Kawano; Kosuke Fujita; Daishi Okuda; Mitsuki Kawabe; Kazuhisa Yamada; Ayana Suzumura; Shu Kachi; Hiroki Kaneko; Hiroyuki Komatsu; Yoshihiko Usui; Hiroshi Goto; Koji M. Nishiguchi
• Keywords: Torque teno virus; Etiology

Abstract Importance Torque teno virus positivity in the aqueous humor of uveitis patients could be associated with systemic immunodeficiency. Objective We explored correlation between presence torque and clinical information, including immunodeficiency history. Design This was a retrospective, cross-sectional study. Setting All participants were recruited at Nagoya University Hospital, Tokyo Medical or Yokkaichi Municipal Hospital April 2017 March 2022. Participants The 58 suspected infectious etiology 24 controls cataract age-related macular degeneration. Main Outcomes Measures used quantitative polymerase chain reaction to test all subjects for multiplex common ocular pathogens. When possible, both serum samples tested. Ocular compared age, sex, history logistic analysis. Results found 7 31 cases (23%) herpetic uveitis, 3 27 (11%) nonherpetic 0 (0%). Among herpes infection, (43%) cytomegalovirus retinitis, 1 12 (8%) iridocyclitis, (14%) acute retinal necrosis, 2 4 (50%) Epstein–Barr virus–related uveitis. Cytomegalovirus retinitis showed significantly higher rate infection than ( P = .008). Serum analysis revealed 9 10 (90%) 8 (100%). Age- gender-adjusted .01), but no correlations gender, viral pathogenic type. Conclusion Relevance study that correlated suggests is biomarker immunity. Key points Question What (TTV) characteristics these patients? Findings In this included 82 patients, TTV present 39% underlying 8% without immunodeficiency; findings statistical significance. Meaning may represent