Lifelong tissue memory relies on spatially organised dedicated progenitors located distally from the injury

• DOI: 10.1101/2023.02.02.526841
• Publication Date: 2023-02-03T10:45:17Z
• Authors: Chiara Levra Levron; Mika Watanabe; Valentina Proserpio; Gabriele Piacenti; Andrea Lauria; Stefan Kaltenbach; Takuma Nohara; Francesca Anselmi; Carlotta Duval; Daniela Donna; Denis Baev; Ken Natsuga; Tzachi Hagai; Salvatore Oliviero; Giacomo Donati
• Keywords: Priming (agriculture); Progenitor

Abstract It is believed epithelial cells that have participated in a wound repair elicit more efficient but locally restricted response to future injuries. However here we show the cell adaptation resulting from localised tissue damage has wide spatial impact at scale not previously noticed. We demonstrate away injured site, after first injury specific stem population gives rise long term wound-memory progenitors residing their own niche of origin. Notably these taken part healing become pre-activated through priming . This differs classical features trained immunity shown be adopted by other cells. Our newly identified wound-distal memory display cell-autonomous transcriptional state leading an enhanced ability can partially recapitulated epigenetic perturbation even absence injury. Importantly, harmful consequences repair, such as exacerbated tumorigenesis, occur within primed and follow distribution. Overall, sub-organ relies on spatially organised memory-dedicated progenitors, characterised actionable state, predisposes tumour onset.