Coupled Biomechanical and Ionic Excitability in Developing Neural Cell Networks

• DOI: 10.1101/2023.02.15.528510
• Publication Date: 2023-02-16T08:20:12Z
• Authors: Sylvester J. Gates; Phillip Alvarez; Kan Cao; Kate O’Neill; Wolfgang Losert
• Keywords: Dynamics

Abstract Waves and oscillations play a key role in the flow processing of information brain. Recent work has demonstrated that addition to electrical activity, biomechanical signaling can also be excitable thus capable self-sustaining waves. Here we measured dynamics actin polymerization neural precursor cells throughout their differentiation into populations neurons astrocytes. Fluorescence-based live-cell imaging allowed us analyze conjunction with calcium signals. Actin showed rhythmic character, localized mostly processes, changes scale associated differentiation. Furthermore, impact ionic dynamics, an increase frequency bursts accompanied by decrease cell-cell correlations when is inhibited. This cytoskeletal on coupling cell suggests brain may able harness both electrical/ionic excitability.