Vascular oxidative stress causes neutrophil arrest in brain capillaries, leading to decreased cerebral blood flow and contributing to memory impairment in a mouse model of Alzheimer’s disease

• DOI: 10.1101/2023.02.15.528710
• Publication Date: 2023-02-16T03:40:13Z
• Authors: Nancy E. Ruiz-Uribe; Oliver Bracko; Madisen Swallow; Argen Omurzakov; Sabyasachi Dash; Hiroki Uchida; David Xiang; Mohammad Haft-Jav...; Kaja Falkenhain; Michael E. Lamont; Muhammad Ali; Brendah N. Njiru; Hsin-Yun Chang; Adrian Y Tan; Jenny Z Xiang; Costantino Iadecola; Laibaik Park; Teresa Sanchez; Nozomi Nishimura; Chris B. Schaffer
• Keywords: Memory Impairment

In this study, we explore the role of oxidative stress produced by NOX2-containing NADPH oxidase as a molecular mechanism causing capillary stalling and cerebral blood flow deficits in APP/PS1 mouse model AD.