Genomic Sequencing Surveillance and Antigenic Site Mutations of Respiratory Syncytial Virus in Arizona, USA

• DOI: 10.1101/2023.06.16.23291299
• Publication Date: 2023-06-20T23:10:13Z
• Authors: LaRinda A. Holland; Steven C. Holland; Matthew F. Smith; Victoria R. Leonard; Vel Murugan; Lora Nordstrom; Mary Mulrow; Raquel Salgado; Michael White; Efrem S. Lim

AbstractWe conducted Respiratory Syncytial Virus (RSV) genomic sequencing surveillance of 100 RSV-A and 27 RSV-B specimens collected between November 2022 and April 2023 in Arizona, USA. We identified mutations in the pre-fusion F protein antigenic sites in both RSV-A and RSV-B. Continued genomic surveillance will be important to ensure RSV vaccine effectiveness.