Distinct genetic underpinnings of inter-individual differences in the sensorimotor-association axis of cortical organisation
Association (psychology)
DOI:
10.1101/2023.07.13.548817
Publication Date:
2023-07-13T20:35:21Z
AUTHORS (7)
ABSTRACT
The topological differentiation of sensorimotor and association cortical regions along a sensorimotor-association (S-A) axis has undergone profound evolutionary change the mammalian lineage. In humans, patterns gene expression, microstructure, functional connectivity have been shown to vary systematically such S-A axis. Despite robust spatial relationships between these different neurobiological traits, whether common genetic pressures shape across traits remains poorly understood. this study, we exploit observed pervasive inter-individual variation in capture its architecture study shared sources structure-function relationships. To do so, applied structural equation modeling framework, which reduced issue measurement error heterogeneity cortex impact on relationship estimates. We then used relatedness pairs twins removed intra-individual differences focus reliable Notwithstanding highly heritable microstructure organisation, contrary group-level findings, our results indicate distinct effects properties. Together, observations challenge notion cause for Our approach highlights diversity origins brain features that co-vary axis, is key interrogating variability organisation consequences cognition.
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