Synaptic Basis of Behavioral Timescale Plasticity

• DOI: 10.1101/2023.10.04.560848
• Publication Date: 2023-10-06T07:25:26Z
• Authors: Kevin C. Gonzalez; Adrian Negrean; Zhenrui Liao; Franck Polleux; Attila Losonczy
• Keywords: Nonsynaptic plasticity; Synaptic scaling; Homosynaptic plasticity

Abstract Learning and memory are fundamental to adaptive behavior cognition. Various forms of synaptic plasticity have been proposed as cellular substrates for the emergence feature selectivity in neurons underlying episodic memory. However, despite decades work, our understanding how underlies encoding remains limited, largely due a shortage tools technical challenges associated with visualization at single-neuron resolution awake-behaving animals. Behavioral Timescale Synaptic Plasticity (BTSP) postulates that inputs active during seconds-long time window preceding immediately following large depolarizing plateau spike potentiated, while outside this depressed. We experimentally tested model vivo mice using an all-optical approach by inducing place fields (PFs) single CA1 pyramidal (CA1PNs) monitoring spatiotemporal tuning individual dendritic spines changes their corresponding weights. identified asymmetric kernel resulting from bidirectional modifications weights around burst induction. Surprisingly, work also uncovered compartment-specific differences magnitude temporal expression between basal oblique dendrites CA1PNs. Our results provide first experimental evidence linking rapid spatial hippocampal neurons, critical prerequisite