Pharmacological enhancement of dopamine neurotransmission does not affect illusory pattern perception

• DOI: 10.1101/2023.10.24.563723
• Publication Date: 2023-10-27T22:55:12Z
• Authors: Elke Smith; Simon Michalski; Kilian Knauth; Deniz Tuzsus; Hendrik Theis; Thilo van Eimeren; Jan Peters
• Keywords: Male; Adult; 0301 basic medicine; Dopamine; Dopamine Agents; Bayes Theorem; Illusions; Synaptic Transmission; Levodopa; Young Adult; 03 medical and health sciences; Double-Blind Method; Pattern Recognition, Visual; Humans; Female; Research Article: New Research

AbstractPsychotic symptoms and delusional belief have been linked to dopamine transmission in both healthy and clinical samples and are assumed to result at least in part from perceiving illusory patterns in noise. However, the existing literature on the role of dopamine in detecting patterns in noise is inconclusive. To address this issue, we assessed the effect of manipulating dopaminergic neurotransmission on illusory pattern perception in healthy individuals (n= 48,n= 19 female) in a double-blind placebo-controlled within-subjects design (see preregistration athttps://osf.io/a4k9j/). We predicted individuals on vs. off L-DOPA to be more likely to perceive illusory patterns, specifically objects in images containing only noise. Using a signal detection model, however, we found no credible evidence that L-DOPA compared to placebo increased false alarm rates. Further, L-DOPA did not modulate measures of accuracy, discrimination sensitivity and response bias. In all cases, Bayesian statistics revealed strong evidence in favour of the null hypothesis Future studies should address possible dose-dependent effects and differential effects in healthy vs. clinical samples.