RUNX1 suppresses breast cancer stemness and tumor growth

• DOI: 10.1101/315093
• Publication Date: 2018-05-04T22:00:10Z
• Authors: Deli Hong; Andrew J. Fritz; Kristiaan H. Finstad; Mark P. Fitzgerald; Adam L. Viens; Jon Ramsey; Janet L. Stein; Jane B. Lian; Gary S. Stein
• Keywords: RUNX1; Ectopic expression

Summary Recent studies have revealed that mutations in the transcription factor Runx1 are prevalent breast tumors. Yet, how loss of contributes to cancer (BCa) remains unresolved. We demonstrate for first time represses stem cell (BCSC) phenotype and consequently, functions as a tumor suppressor cancer. ectopic expression MCF10AT1 MCF10CA1a BCa cells reduces (60%) migration, invasion vivo growth mouse mammary fat pad (P<0.05). is decreased BCSCs, overexpression suppresses tumorsphere formation BCSC population. Furthermore, inhibits Zeb1 expression, while depletion activates epithelial-mesenchymal transition. Mechanistically through repression activity. This key regulation BCSCs by may be shared other epithelial carcinomas, highlighting importance solid