B-cell enforced expression of the mouse ortholog of MYD88L265P is responsible for Waldenström-like B-cell lymphoma

• DOI: 10.1101/794024
• Publication Date: 2019-10-06T20:54:12Z
• Authors: Catherine Ouk; Lilian Roland; Alexis Saintamand; Nathalie Gachard; Morgane Thomas; Mélanie Devéza; Nathalie Faumont; Jean Feuillard; Christelle Vincen...
• Keywords: PAX5

Abstract Here, we created a conditional transgenic mouse model with insertion of sequence coding for both MYD88 L252P and the Yellow Fluorescent Protein (YFP) into rosa26 -locus. B-cell specific induction transgene constantly led to spleen enlargement expansion YFP positive B-cells in 8-12 month-old mice, moderate proliferation increase. Being clonal or oligoclonal, these exhibited marked morphological immunophenotypic lymphoplasmocytic aspect plasma cell transcriptomic signature serum immunoglobulin M peak. Therefore, continuous activation mice can lead on its own lymphoma close Waldenström Macroglobulinemia. Key point enforced expression leads indolent IgM