Sip2p and its partner Snf1p kinase affect aging in S. cerevisiae

• DOI: 10.1101/gad.14.15.1872
• Publication Date: 2021-11-15T03:33:37Z
• Authors: Kaveh Ashrafi; Stephen S. Lin; Jill K. Manchester; Jeffrey I. Gordon
• Keywords: Extrachromosomal DNA; Hexokinase; Senescence

For a number of organisms, the ability to withstand periods nutrient deprivation correlates directly with lifespan. However, underlying molecular mechanisms are poorly understood. We show that deletion N-myristoylprotein, Sip2p, reduces resistance and shortens lifespan in Saccharomyces cerevisiae. This reduced is due accelerated aging, as defined by loss silencing from telomeres mating loci, nucleolar fragmentation, accumulation extrachromosomal rDNA. Genetic studies indicate sip2Delta produces its effect on aging increasing activity Snf1p, serine/threonine kinase involved regulating global cellular responses glucose starvation. Biochemical analyses reveal yeast age, hexokinase increases does ATP NAD(+) content. The change metabolism represents new correlate occurs greater degree, at earlier generational ages cells. Sip2p Snf1p provide links between regulation energy utilization aging.