Genetic interaction between Wnt/β-catenin and BMP receptor signaling during formation of the AER and the dorsal–ventral axis in the limb

• DOI: 10.1101/gad.263003
• Publication Date: 2003-08-15T21:19:01Z
• Authors: Natalia Soshnikova; Dietmar Zechner; Joerg Huelsken; Yuji Mishina; Richard R. Behringer; Makoto M. Taketo; E. Bryan Crenshaw; Walter Birchmeier
• Keywords: Beta-catenin; Apical ectodermal ridge; Limb development

By conditional gene ablation in mice, we found that β-catenin, an essential downstream effector of canonical Wnt signaling, is a key regulator formation the apical ectodermal ridge (AER) and dorsal–ventral axis limbs. generation compound mutants, also show β-catenin acts BMP receptor IA AER induction, but upstream or parallel patterning. Thus, patterningof limbs are tightly controlled by intricate interplay between Wnt/β-catenin signaling.