A Novel Class of Herbicides (Specific Inhibitors of Imidazoleglycerol Phosphate Dehydratase)

• DOI: 10.1104/pp.107.3.719
• Publication Date: 2016-10-18T01:53:34Z
• Authors: I. Mori; R. Fonne-Pfister; Si. Matsunaga; S. Tada; Y. Kimura; G. Iwasaki; Ji. Mano; M. Hatano; T. Nakano; Si. Koizumi; A. Scheidegger; K. Hayakawa; D. Ohta
• Keywords: Enzyme Inhibition

A new mode of herbicidal action was established by finding specific inhibitors imidazoleglycerol phosphate dehydratase, an enzyme histidine (His) biosynthesis. Three triazole phosphonates inhibited the reaction with Ki values 40 [plus or minus] 6.5, 10 1.6, and 8.5 1.4 nM, respectively, were highly cytotoxic to cultured plant cells. This effect completely reversed addition His, proving that cytotoxicity primarily caused inhibition His These showed wide-spectrum, postemergent activity at application rates ranging from 0.05 2 kg/ha.