Development of W-Type Four-Core Fiber-Based WaveFlex Sensor for Enhanced Detection of Shigella Sonnei Bacteria Using Engineered Nanomaterials

• DOI: 10.1109/jlt.2024.3379290
• Publication Date: 2024-03-19T18:27:13Z
• Authors: Chaofan Gu; Ragini Singh; Guoru Li; Qinglin Wang; Feng-Zhen Liu; Rui Min; Daniele Tosi; Bingyuan Zhang; Santosh Kumar
• Keywords: Shigella sonnei; Nanomaterials

Shigella, a highly infectious and pathogenic Gram-negative bacterium, is widely prevalent in everyday food items, prompting significant research due to its potential hazards. Addressing the need for Shigella detection, this study introduces WaveFlex biosensor based on localized surface plasmon resonance (LSPR) using fiber optics. The sensor tailored detect specific subspecies of <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Shigella</i> , specifically sonnei (S. sonnei). It fabricated combination multimode (MMF) four-core (FCF), creating core-mismatched W-type structure designed efficient mode coupling. Furthermore, enhanced with utilization nanomaterials, including cerium oxide nanorods (CeO2-NRs), zinc nanowires (ZnO-NWs), copper selenide@gold nanocomposites (Cu3Se2@Au-NCs). CeO2-NRs ZnO-NWs contribute improve biocompatibility increase area antibody functionalization, while Cu3Se2@Au-NCs promote LSPR effect enhance sensing performance. To specificity, optical coated these engineered nanomaterials functionalized S. antibody. results work showcase effective detection bacteria by proposed sensor, offering exceptional sensitivity (0.28 nm/(CFU/mL)), low limit (LoD) 0.96 CFU/mL, swift time 10 minutes. These findings underscore sensor's widespread applications areas such as safety, medical diagnostics, environmental monitoring. This significantly advances bacterial technology contributes assurance public health safety.