Total Iron-Overload Measurement in the Human Liver Region by the Magnetic Iron Detector

• DOI: 10.1109/tbme.2010.2053204
• Publication Date: 2010-06-23T19:47:57Z
• Authors: M Marinelli; B Gianesin; M Balocco; P Beruto; C Bruzzone; P Carrara; P Gallusi; A Macco; M Musso; E Oliveri; S Pelucchi; G Sobrero; R Villa; G L Forni
• Keywords: SIGNAL (programming language)

An accurate assessment of body iron accumulation is essential for the diagnosis and therapy overload in diseases, such as hemochromatosis, thalassemia other forms severe anemias. The magnetic detector (MID) a room-temperature susceptometer, which measures total liver. Since February 2005, about 600 patients have been assessed using this device. obtained by calculating difference between measured magnetization signal patient patient's background signal. latter that would generate with normal content. This study presents method healthy volunteers application same to burden order evaluate their overload. present MID sensitivity 0.8 g reproducibility measurement lower than 0.5 g. does not require calibration liver biopsies. We correlated measurements results 26 biopsies (R = 0.62), 64 superconducting quantum interference device susceptometer 0.79), 666 serum ferritin concentration 0.72), 41 MRI-R2* 0.71).