The role of TNF‐α as a potential marker for acute cutaneous lupus erythematosus in patients with systemic lupus erythematosus

• DOI: 10.1111/1346-8138.17355
• Publication Date: 2024-07-04T13:25:35Z
• Authors: Zhan Jinshan; Qu Yong; Chen Fangqi; Cao Juanmei; Li Min; Huang Changzheng
• Keywords: Male; Adult; Tumor Necrosis Factor-alpha; Middle Aged; Severity of Illness Index; Young Adult; 03 medical and health sciences; 0302 clinical medicine; ROC Curve; Risk Factors; Acute Disease; Lupus Erythematosus, Cutaneous; Humans; Lupus Erythematosus, Systemic; Female; Biomarkers

Acute cutaneous lupus erythematosus (ACLE) is closely associated with systemic symptoms in (SLE). This study aimed to identify potential biomarkers for ACLE and explore their association SLE enable early prediction of treatment targets the future. In total, 185 SLE-diagnosed patients were enrolled categorized into two groups: those without involvement. After conducting logistic regression analysis differentiating factors, we concluded that tumor necrosis factor-alpha (TNF-α) an independent risk factor ACLE. Analysis receiver operating characteristic revealed area under curve 0.716 TNF-α. Additionally, both TNF-α are positively correlated disease activity. shows promise as a biomarker ACLE, patients, may serve clear indicator moderate-to-severe