Smurfness‐based two‐phase model of ageing helps deconvolve the ageing transcriptional signature

• DOI: 10.1111/acel.13946
• Publication Date: 2023-10-12T07:26:17Z
• Authors: Flaminia Zane; Hayet Bouzid; Sofia Sosa Marmol; Mira Brazane; Savandara Besse; Julia Lisa Molina; Céline Cansell; Fanny Aprahamian; Sylvère Durand; Jessica Ayache; Christophe Antoni...; Nicolas Todd; Clément Carré; Michael Rera
• Keywords: Healthy ageing

Ageing is characterised at the molecular level by six transcriptional 'hallmarks of ageing', that are commonly described as progressively affected time passes. By contrast, 'Smurf' assay separates high-and-constant-mortality risk individuals from healthy, zero-mortality individuals, based on increased intestinal permeability. Performing whole body total RNA sequencing, we found Smurfness distinguishes changes associated with chronological age those biological age. We show heterogeneity increases in non-Smurf preceding other five hallmarks ageing specifically Smurf state. Using this approach, also devise targeted pro-longevity genetic interventions delaying entry anticipate attention to evolutionary conserved phenotype will bring about significant advances our understanding mechanisms ageing.