Accelerated biological aging, healthy behaviors, and genetic susceptibility with incidence of stroke and its subtypes: A prospective cohort study

• DOI: 10.1111/acel.14427
• Publication Date: 2024-12-05T06:14:51Z
• Authors: Xuening Zhang; Hao Zhao; Zilin Li; Xinjie Liu; Yurong Zhang; Ning Yang; Tongchao Zhang; Xiaorong Yang; Ming Lu
• Keywords: Stroke

Abstract Stroke risk increases with chronological age, but the relationship biological age (BA) acceleration is poorly understood. We aimed to examine association between BA and incident stroke its subtypes, explore modifying effects on genetic susceptibility, assess how mediates effect of behavior score. studied 253,932 UK Biobank participants computed two measures (Klemera‐Doubal Method [KDM], Phenotypic Age [PhenoAge]), calculated by regressing age. The polygenic score (PRS) was derived from 87 loci. behaviors based diet, physical activity, tobacco/nicotine, sleep, BMI. During a median follow‐up 13.6 years, 5460 strokes, 4337 ischemic (IS), 951 intracerebral hemorrhage (ICH), 553 subarachnoid (SAH) cases were documented. Adjusting for confounding factors, each standard deviation increase in associated higher risk: KDM‐BA acceleration, (HR = 1.28, 95% CI 1.25–1.32), IS (1.32, 1.28–1.36), ICH (1.15, 1.08–1.23), SAH (1.16, 1.07–1.27); PhenoAge (1.22, 1.19–1.25), (1.26, 1.22–1.29), (1.08, 1.02–1.16), 1.00–1.18). Compared lowest PRS those highest had (KDM‐BA acceleration: 2.19, 1.85–2.59; 2.03, 1.69–2.42). Additionally, there an additive interaction PRS. mediation proportion associations subtypes ranged 15.84% 33.08%. may raise risk, especially high risk. Maintaining healthy help mitigate this