Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction

• DOI: 10.1111/adb.12496
• Publication Date: 2017-02-24T00:32:51Z
• Authors: Gunnar W. Reginsson; Andres Ingason; Jack Euesden; Gyda Bjornsdottir; Sigurgeir Olafsson; Engilbert Sigurdsson; Hogni Oskarsson; Thorarinn Tyrfing...; Valgerdur Runarsd...; Ingunn Hansdottir; Stacy Steinberg; Hreinn Stefansson; Daniel F. Gudbjar...; Thorgeir E. Thorg...; Kari Stefansson
• Keywords: Polygenic risk score; Alcohol use disorder; Etiology

Abstract We use polygenic risk scores (PRSs) for schizophrenia (SCZ) and bipolar disorder (BPD) to predict smoking, addiction nicotine, alcohol or drugs in individuals not diagnosed with psychotic disorders. Using PRSs 144 609 subjects, including 10 036 admitted in‐patient treatment 35 754 smokers, we find that diagnoses of various substance disorders smoking associate strongly SCZ ( P = 5.3 × −50 –1.4 −6 ) BPD 1.7 −9 –1.9 −3 ), showing shared genetic etiology between psychosis addiction. standardized scaled a unit increase doubling the corresponding disorder, odds ratios range from 1.19 1.31 SCZ‐PRS, 1.07 1.29 BPD‐PRS. Furthermore, show as regular becomes more stigmatized less prevalent, these biological factors gain importance determinants behavior.