Does polygenic risk for substance‐related traits predict ages of onset and progression of symptoms?

• DOI: 10.1111/add.16210
• Publication Date: 2023-04-18T03:44:48Z
• Authors: Henry R. Kranzler; Richard Feinn; Heng Xu; Brendan L. Ho; Divya Saini; Olivia R. Nicastro; Anya Jacoby; Sylvanus Toikumo; Joel Gelernter; Emily E. Hartwell; Rachel L. Kember
• Keywords: Alcohol use disorder; Polygenic risk score; Alcohol Dependence; Moderation; Substance dependence

Genetic risk can influence disease progression. We measured the impact of genetic for substance use disorders (SUDs) on onset and progression symptoms.