External‐beam radiation therapy versus surgery in the treatment of hepatocellular carcinoma with inferior vena cava/right atrium tumor thrombi

• DOI: 10.1111/ajco.13194
• Publication Date: 2019-07-16T08:39:52Z
• Authors: Yong Li; Fenghua Liu; Liang Yang; Yan Meng; Aijun Li; Mianshun Pan
• Keywords: External beam radiotherapy; Univariate analysis

Abstract Background Both surgery and external‐beam radiotherapy are effective treatments for hepatocellular carcinoma (HCC) patients with inferior vena cava/right atrium (IVC/RA) tumor thrombi. At present, it is not clear which modality more suitable. We therefore compared outcomes between these patients. Methods retrospectively reviewed 108 HCC IVC/RA thrombi who were referred ( n = 51) 57) at three institutions. Different surgical methods selected according to the classification of thrombus. Radiotherapy was designed focus on primary intrahepatic tumors Predictors time progression (TTP) identified by using univariate multivariate analyses. Results The median TTP significantly longer in group than (5.0 months vs 4.2 months; P 0.010). analysis revealed that independent factors predicting shorter treatment (HR 0.577; 95% CI, 0.385–0.865; 0.008) size larger 10 cm 0.561; 0.342–0.919; 0.022). survival times groups 12.8 14.5 months, respectively; two did have a significant difference 0.466). Conclusions For thrombi, smaller may predict TTP. Compared complicated surgery, radiotherapy, as noninvasive modality, be likely accepted.