Liver resection for large and huge hepatocellular carcinoma: Predictors of failure, recurrence patterns, and prognoses

• DOI: 10.1111/ajco.13777
• Publication Date: 2022-04-11T13:28:23Z
• Authors: Cailing Xiang; Yating Xiao; Zhongzhi Ma; Yuchong Peng; Xun Li; Xianhai Mao; Lequn Li
• Keywords: Subgroup analysis; Univariate analysis

Abstract Background Characteristic symptoms and signs are often absent in patients with hepatocellular carcinoma (HCC). As a result, many not diagnosed until their tumors have grown to large (> 5cm) or huge sizes 10cm). Liver resection has traditionally been reserved for small HCC, but more recently it is being used tumors. The aim of this study was determine risk predictors recurrence, patterns survival rates HCC who underwent curative liver resection. Materials methods We retrospectively identified subgroup diameters 5 cm larger. Overall (OS) recurrence‐free (RFS) were calculated using the Kaplan–Meier method. Univariate multivariate Cox regression analyses performed investigate potential factors recurrence death. Results Among 897 patients, median follow‐up 48 (range, 5–140) months. 1‐, 3‐, 5‐year RFS 51.6%, 36.1%, 30.1%, respectively, OS 80.2%, 55.4%, 47.7%, respectively. Significant independent preoperative satellite nodule (HR = 2.25; 95% CI, 1.17–4.31; p .02), AFP levels above 400 ng/ml 1.23; 1.04–1.45; .01), margins 1 less 1.21; 1.00–1.46; .047), cirrhosis 2.64; 2.13–3.28; < .001), microvascular invasion 1.71; 1.45–2.20; .001). All these except narrow margin also OS. Conclusions Hepatic without hepatic vascular invasion, extrahepatic metastases, severe chronic disease results acceptable long‐term outcomes.