Depression and Frailty in Patients With End-Stage Liver Disease Referred for Transplant Evaluation

• DOI: 10.1111/ajt.13639
• Publication Date: 2015-11-28T07:06:43Z
• Authors: D.C. Cron; J.F. Friedman; G.S. Winder; A.E. Thelen; J.E. Derck; J.W. Fakhoury; A.D. Gerebics; M.J. Englesbe; C.J. Sonnenday
• Keywords: Depression; Liver disease

End-stage liver disease (ESLD) patients are believed to have a high prevalence of depression, although mental health in ESLD has not been studied comprehensively. Further, the relationship between depression and severity is unclear. Using baseline data from large prospective cohort study (N = 500) frailty patients, we association with depression. Frailty was assessed five-component Fried Index. Patients were assigned composite score 0 5, scores ≥3 considered frail. Depression using 15-question Geriatric Scale, threshold ≥6 indicating depression; 43.2% frail 39.4% depressed (median 4, range 0–15). In multivariate analysis, significantly associated (odds ratio 2.78, 95% confidence interval 1.87–4.15, p < 0.001), whereas model for After covariate adjustment, 3.6 times higher most-frail than least-frail patients. conclusion, common strongly but disease. Transplant centers should address issues frailty; targeted interventions may lower burden illness this population.