Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients

• DOI: 10.1111/ajt.15549
• Publication Date: 2019-08-02T17:13:41Z
• Authors: Luc Colas; Emmanuel F. Mongodin; Emmanuel Montassier; Mélanie Chesneau; Pierrick Guerif; Lauren Hittle; Magali Giral; Jonathan S. Bromberg; Sophie Brouard
• Keywords: Immunosuppression; Regimen

Host-microbiota interactions can modulate the immune system both at local and systemic levels, with potential consequences for organ transplantation outcomes. In this study, we hypothesized that differences in urinary microbiome following kidney would be associated posttransplantation status: stable, minimally immunosuppressed, or tolerant. One hundred thirteen urine samples from stable (n = 51), immunosuppressed 19), spontaneously tolerant 16) patients, paired age-matched controls 27) were profiled compared to each other a taxonomic level special interest immunosuppressive regimen. All comparisons correlations adjusted on sex time posttransplantation. Our results highlighted unique specific microbiota spontaneous tolerance characterized by high diversity clear Proteobacteria profile. Finally, report profile is (1) impacted gender, (2) inversely correlated drugs (calcineurin inhibitors mammalian target of rapamycin inhibitors), (3) time.